• Nancy L Greengold, Rita Shane, Philip Schneider, Elizabeth Flynn, Janet Elashoff, Cheryl L Hoying, Kenneth Barker, and Linda Burnes Bolton.
• Department of Health Services Research, Cedars-Sinai Health System, Los Angeles, CA 90048, USA. NGreengold@WKHealth.com
• Arch Intern Med. 2003 Oct 27;163(19):2359-67.

BackgroundConcerns about hospital medication safety mount as the pace of new drug releases accelerates.MethodsWe performed a randomized study at 2 hospitals (A and B) to examine whether the medication administration error rate could be decreased by having "dedicated" nurses focus exclusively on administering drugs. "Medication nurses," after receiving a brief review course on safe medication use, were responsible solely for drug delivery for up to 18 patients each. "General nurses," who did not attend the course, provided comprehensive care, including drug delivery, for 6 patients each. A direct observation technique was used to record drug errors, process-variation errors, and total errors.ResultsAt both hospitals combined, the total error rate was 15.7% for medication nurses and 14.9% for general nurses (P<.84). Comparing hospitals, the total error rate for medication nurses at hospital B was significantly higher than it was at hospital A (19.7% vs 11.2%; P<.04). At hospital A, there was a significantly lower error rate for medication nurses than for general nurses in the surgical units (P<.01) but no significant differences in total errors comparing nurse types in the medical units (P<.77).ConclusionsThis trial suggests that use of dedicated medication nurses does not reduce medication error rates. However, subgroup analysis indicates that medication nurses might be useful in some settings. The differences in findings at the 2 hospitals and their differences in medication-use processes reinforce the concept that medication errors are usually related to systems design issues.

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