• J. Cardiothorac. Vasc. Anesth. · Dec 2002

    Time course of neuromuscular blockade with rocuronium in children with intracardiac shunts.

    • Yaacov Gozal, Bella Mints, and Benjamin Drenger.
    • Department of Anesthesiology and Critical Care Medicine, Hadassah University Hospital, Jerusalem, Israel. gozaly@md2.huji.ac.il
    • J. Cardiothorac. Vasc. Anesth. 2002 Dec 1;16(6):737-8.

    ObjectiveTo evaluate the time course of neuromuscular blockade after rocuronium in children with intracardiac shunts.DesignProspective study.SettingUniversity hospital.ParticipantsConsecutive children (n = 52) with intracardiac shunts scheduled for elective cardiac surgery. Participants were allocated to 2 groups according to the direction of the shunt.InterventionsRocuronium, 0.6 mg/kg, was administered for muscle relaxation. The ulnar nerve was stimulated at 20-second intervals with a supramaximal 2-Hz train-of-4 stimulation (TOF-Guard nerve stimulator; Biomet International, Odense, Denmark). The onset time to maximal twitch depression and the time to clinical recovery were compared between the 2 groups.Measurements And Main ResultsThe time to maximal block was significantly faster in children with a right-to-left shunt: 56.8 +/- 5.3 seconds versus 77.1 +/- 6.6 seconds (p = 0.01). There was a tendency to shorter recovery in children with a right-to-left shunt: 42.3 +/- 6.1 minutes versus 55.4 +/- 4.9 minutes (p = NS).ConclusionThis study shows a more rapid onset of rocuronium in children with cyanotic congenital heart disease. In these patients, rocuronium is indicated, particularly for rapid airway control.Copyright 2002, Elsevier Science (USA). All rights reserved.

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