• Rev Bras Anestesiol · Sep 2002

    [Dexmedetomidine: pharmacology and clinical application.].

    • Airton Bagatini, Cláudio Roberto Gomes, Marcelo Zanettini Masella, and Gabrielle Rezer.
    • CET, SBA, SANE.
    • Rev Bras Anestesiol. 2002 Sep 1;52(5):606-17.

    Background And ObjectivesDexmedetomidine is the newest alpha2-adrenergic agonist for clinical application. It has a fast onset, is metabolized by the liver and mostly excreted by the urine. This review aimed at presenting pharmacokinetic and pharmacodynamic profiles of dexmedetomidine and its clinical applications.ContentsDexmedetomidine pharmacokinetic and pharmacodynamic profiles are presented and compared to other alpha2-adrenergic agonist drugs, the prototype of which is clonidine. Cardiac, vascular, neurological and gynecologic procedure outcomes are commented.ConclusionsDexmedetomidine is an innovative drug for sedation and analgesia. Its major qualities are fast onset and titration, allowing for changes in sedation and analgesia depth. In addition, it has a synergism with commonly used anesthetic drugs, with a low incidence of side effects and minor respiratory depression.

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