• Lisa L Larive, Denise H Rhoney, Dennis Parker, William M Coplin, and J Ricardo Carhuapoma.
• Department of Pharmacy Practice, Wayne State University, Detroit, Michigan, USA.
• Neurocrit Care. 2004 Jan 1;1(4):435-40.

IntroductionUse of hypertonic saline (HTS) is gaining acceptance in the neurosciences critical care unit (NCCU) based on its efficacy in reducing cerebral edema and its favorable hemodynamic profile. In the NCCU, unfamiliarity with the use of HTS may result in implementation difficulties. We report our initial experience using HTS, its ability to achieve a hypernatremic state, and adverse effects.MethodsAnalysis of 19 consecutive patients who were admitted to the NCCU and treated with 2 or 3% HTS infusion for cerebral edema (target serum sodium: 145-155 mEq/L) included patient diagnoses, laboratory data, length of treatment, adverse effects, and outcome at discharge. We compared the adverse effects of those patients to a contemporary cohort of patients who received mannitol as the sole form of osmotherapy.ResultsThe HTS cohort had a median age of 46 years (range: 18-70). Median GCS and APACHE II scores were 11 (range: 3-15) and 18 (range: 8-30), respectively. Median length of HTS treatment was 5 days (range: 1-17). Target hypernatremia was achieved in 14 patients (74%), 7 of whom achieved hypernatremia within the first 24 hours. The median number of rescue interventions received for ICP control was 3 (range: 1-30). The adverse effects between the HTS and mannitol cohorts were not found to be significantly different.ConclusionThe use of HTS for cerebral edema requires intensive efforts by the medical team to rapidly achieve and maintain a hypernatremic state. The continuous infusion of HTS was used safely.

18 keywords...

hide…