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J. Clin. Microbiol. · Apr 1999
Case ReportsAspergillus meningitis: diagnosis by non-culture-based microbiological methods and management.
- P E Verweij, K Brinkman, H P Kremer, B J Kullberg, and J F Meis.
- Departments of Medical Microbiology, University Hospital Nijmegen, Nijmegen, The Netherlands. p.verweij@mmb.azn.nl
- J. Clin. Microbiol. 1999 Apr 1;37(4):1186-9.
AbstractThe performance of antibody detection, antigen detection, and Aspergillus genus-specific PCR for diagnosing Aspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with proven infection caused by Aspergillus fumigatus. Immunoglobulin G antibodies directed against Aspergillus were not detected by enzyme-linked immunosorbent assay in CSF or serum. The antigen galactomannan was detected in the CSF 45 days before a culture became positive, and Aspergillus DNA was detected 4 days prior to culture. Decline of the galactomannan antigen titer in the CSF during treatment with intravenous and intraventricular amphotericin B and intravenous voriconazole corresponded with the clinical response to treatment.
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