• Acta paediatrica · Nov 2004

    Randomized Controlled Trial Clinical Trial

    Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children.

    • M Singh, J L Mathew, S Chandra, S Katariya, and L Kumar.
    • Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. meenusingh4@rediffmail.com
    • Acta Paediatr. 2004 Nov 1;93(11):1443-5.

    AimTo compare intrapleural streptokinase and placebo in paediatric empyema.MethodsChildren with empyema greater than stage 5 received intrapleural streptokinase (n = 19) or normal saline (n = 21) along with intercostal drainage. Clinical and serial sonographic outcomes were compared.ResultsAlthough there was no difference in clinical and sonographic outcome, none of the children with stage 7 empyema (multi-loculated empyema) who received streptokinase developed pleural thickening 30 d later.ConclusionThere is no short-term clinical benefit of intrapleural streptokinase in paediatric empyema; this therapy may be reserved for those with stage 7 empyema to prevent pleural thickening in the long term.

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