• Anthony F DiMarco, Yoshiro Takaoka, and Krzysztof E Kowalski.
• Departments of Physiology and Biophysics, Case Western Reserve University, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA. afd3@cwru.edu
• Arch Phys Med Rehabil. 2005 Jun 1;86(6):1200-7.

ObjectiveTo evaluate the usefulness of combined intercostal and diaphragm pacing to maintain independence from mechanical ventilation.DesignA prospective trial.SettingClinical research center at a large tertiary hospital.ParticipantsFour ventilator-dependent subjects with spinal cord injury with only unilateral phrenic nerve function.InterventionDuring an initial surgical procedure, a multipolar epidural disk electrode was positioned on the ventral surface of the upper-thoracic spinal cord via a hemilaminectomy to activate the inspiratory intercostal muscles. A phrenic nerve electrode was implanted unilaterally via the thoracic approach.Main Outcome MeasuresInspired volume production and duration that subjects could be comfortably maintained when off mechanical ventilatory support.ResultsInitial maximum inspired volumes from combined intercostal and diaphragm stimulation ranged between .23 and .93L and significantly increased over the course of reconditioning period to between 0.55 and 1.31L; subjects could be maintained off mechanical ventilation between 16 and 24 hours a day.ConclusionsCombined intercostal and unilateral diaphragm pacing may be a useful therapeutic modality capable of maintaining long-term ventilatory support in patients with only unilateral phrenic nerve function.

21 keywords...

hide…