• Eur J Anaesthesiol Suppl · Jan 1994

    Review

    Interactions of volatile anaesthetics with rocuronium bromide in perspective.

    • S Agoston.
    • Research Group for Experimental Anesthesiology and Clinical Pharmacology, University Hospital, Groningen, The Netherlands.
    • Eur J Anaesthesiol Suppl. 1994 Jan 1;9:107-11.

    AbstractA review of several publications shows that there is general agreement that inhalational anaesthetic agents potentiate the neuromuscular effects of rocuronium in the same order as other similar agents, namely; enflurane and isoflurane > halothane > intravenous anaesthetics. However, such potentiation is not evident during induction and only becomes significant as anaesthesia becomes more prolonged. It is manifest as a prolongation in the duration of action of maintenance doses and a decrease in the recovery rate. During long-lasting procedures in which enflurane or isoflurane are used, smaller than usual maintenance doses or lower infusion rates should be employed.

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