• Exp. Lung Res. · Oct 2007

    Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits.

    • Steven Idell, Ali Azghani, Shande Chen, Kathy Koenig, Andrew Mazar, Lalitha Kodandapani, Khalil Bdeir, Douglas Cines, Irina Kulikovskaya, and Timothy Allen.
    • Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA. steven.idell@uthct.edu
    • Exp. Lung Res. 2007 Oct 1;33(8-9):419-40.

    AbstractThe authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA and tPA reversed loculations at 96 hours after injury P < or = .001, whereas low-molecular-weight urokinase and the scuPA mutant were ineffective. scuPA and tPA generated inhibitor complexes, induced fibrinolytic activity, and quenched plasminogen activator-1 activity in pleural fluids. The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective.

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