• Rev Neurol France · Nov 2001

    [Respiratory disorders during sleep in amyotrophic lateral sclerosis].

    • W Camu.
    • Service Neurologie B, Hôpital Gui de Chauliac, 34295 Montpellier. w-camu@chu-montpellier.fr
    • Rev Neurol France. 2001 Nov 1;157(11 Pt 2):S152-5.

    AbstractAmyotropic lateral sclerosis is a severe degenerative disease of the nervous system. Progressive death of central and peripheral motor neurons leads to rapidly extensive paralysis of the four limbs, the bulbar region and the respiratory system. Sleep respiratory disorders is a useful sign to follow in these patients. Apnea is generally central rather than obstructive. Hypoventilation, particularly during REM sleep has been reported and causes nocturnal desaturation. These patients also appear to have a disrupted sleep pattern with a longer phase I and a shorter total duration of sleep. These nocturnal respiratory disorders observed in amyotropic lateral sclerosis are similar to those observed in muscle diseases. Management must however be undertaken very early in these patients because outcome can be rapidly fatal after the development of significant desaturation. Nasal ventilation can improve not only quality of life but also life expectancy for these patients.

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