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Antimicrob. Agents Chemother. · Nov 2014
Validation of a model to predict the risk of nephrotoxicity in patients receiving colistin.
- Kady Phe, Michael L Johnson, Hannah R Palmer, and Vincent H Tam.
- Department of Pharmacy, Baylor St. Luke's Medical Center, Houston, Texas, USA Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA.
- Antimicrob. Agents Chemother. 2014 Nov 1;58(11):6946-8.
AbstractDespite concerns about its nephrotoxicity, colistin often remains the only effective agent for treating multidrug-resistant Gram-negative infections. Published studies have reported a wide range of nephrotoxicity risk factors. To assess the clinical utility of various models, we compared their performances for predicting the risk of nephrotoxicity. We identified a model demonstrating reasonable overall risk assessment, with an observed/expected ratio of 1.29 (95% confidence interval [CI], 0.68 to 1.90) and a positive predictive value of 87.5% for identifying patients at high risk of developing nephrotoxicity.Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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