• Ann Emerg Med · May 1981

    Phenytoin: the drug of choice in tricyclic antidepressant overdose?

    • J A Uhl.
    • Ann Emerg Med. 1981 May 1;10(5):270-4.

    AbstractTricyclic antidepressants seem to have at least three types of effect on the heart: anticholinergic, adrenergic, and quinidine-like. Although the therapeutic emphasis in tricyclic antidepressant overdose has been on reversing the anticholinergic effects with physostigmine, there is considerable evidence suggesting that the life-threatening manifestations of tricyclic antidepressant overdose--the conduction defects, bradyarrhythmias, heart block, etc--are much more like quinidine and are more appropriately treated with phenytoin, or other drugs which enhance intracardiac conduction and myocardial contractility.

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