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- A Borgeat, O H Wilder-Smith, C H Wilder-Smith, M Forni, and P M Suter.
- Department of Anaesthesiology, Geneva University Hospital, Switzerland.
- Oncology. 1993 Nov 1;50(6):456-9.
Abstract20 consecutive patients with nausea and vomiting secondary to cisplatin chemotherapy uncontrolled by serotonin-antagonist and corticosteroid prophylaxis during their first cycle received adjuvant propofol. This new anesthetic agent was added at subhypnotic doses, i.e. 1 mg/kg/h, as a continuous intravenous infusion during the two subsequent chemotherapy cycles. In 85 and 90% of patients, nausea and vomiting were prevented in the first 24 h following the first and second propofol-supplemented chemotherapy cycles respectively. 24-72 h postchemotherapy, this side effect remained suppressed in 75 and 70% of patients, respectively. Patients' comfort and appetite were improved. All 20 subjects preferred the propofol-containing regimen.
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