• J. Perianesth. Nurs. · Aug 2015

    Review

    Lipid Emulsion in Treatment of Local Anesthetic Toxicity.

    • Shawn Collins, Judy Neubrander, Zachary Vorst, and Brad Sheffield.
    • J. Perianesth. Nurs. 2015 Aug 1; 30 (4): 308-20.

    AbstractEpidural, spinal, regional, local, and intravenous administration of local anesthetics (LAs) is a cornerstone of anesthetic practice. LA toxicity is a grave consequence that is of great significance to anesthesia providers. Outcomes of LA toxicity range from inconvenient symptoms such as tinnitus, twitching, and hypotension to seizures; cardiovascular or respiratory collapse; and death. Lipid emulsion has emerged as a potential "magic bullet" in treating LA toxicity. This literature review provides background information and proposed mechanisms of action for LAs and lipid emulsion as well as animal experiments and a case report that speak to the effectiveness of lipid emulsion in the face of LA toxicity. Copyright © 2015 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

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