• J Clin Apher · Oct 2015

    Case Reports

    Therapeutic plasma exchange as treatment for propofol infusion syndrome.

    • Phillip D Levin, Valentin Levin, Charles Weissman, Charles L Sprung, and Deborah Rund.
    • Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
    • J Clin Apher. 2015 Oct 1; 30 (5): 311-3.

    AbstractPropofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality. There is no specific therapy. A 16-year-old with head injury and status epilepticus is described. Three days after seizure resolution, whilst receiving propofol, he developed severe lactic acidosis, rhabdomyolysis, and hemodynamic instability. Suspected PRIS was treated with a single session of therapeutic plasma exchange (TPE). This was associated with immediate improvement in hemodynamic status, resolution of lactic acidosis within 24 h, normalization of CPK over 10 days, and a subsequent full recovery. TPE is suggested as a novel therapy for PRIS.© 2015 Wiley Periodicals, Inc.

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