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Randomized Controlled Trial
Effects of interferon beta-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis.
- Iris-Katharina Penner, Brigitte Stemper, Pasquale Calabrese, Mark S Freedman, Chris H Polman, Gilles Edan, Hans-Peter Hartung, David H Miller, Xavier Montalbán, Frederik Barkhof, Dirk Pleimes, Vivian Lanius, Christoph Pohl, Ludwig Kappos, and Rupert Sandbrink.
- Department of Cognitive Psychology and Methodology, University of Basel, Missionsstrasse 60/62, Basel, Switzerland. ik.penner@unibas.ch
- Mult. Scler. 2012 Oct 1;18(10):1466-71.
BackgroundCognitive dysfunction occurs at the earliest stages of multiple sclerosis (MS), including the stage of clinically isolated syndrome (CIS).MethodsWe evaluated the impact of interferon beta-1b (IFNβ-1b) 250 µg on cognitive performance during the CIS stage in the BENEFITstudy. Cognition was assessed by Paced Auditory Serial Addition Test-3" (PASAT-3") scores.ResultsImprovement in PASAT-3" score from baseline to year two was greater for IFNβ-1b treatment than placebo in patients not reaching clinically definite MS (CDMS) by year two. The treatment effect was maintained at year five and was statistically significant.ConclusionsTo conclude, early IFNβ-1b treatment had a sustained positive effect on PASAT-3" score over the 5-year BENEFIT study.
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