• Caio Marcio Barros de Oliveira, Rioko Kimiko Sakata, Alexandre Slullitel, Reinaldo Salomão, Vera Lucia Lanchote, and Adriana Machado Issy.
• Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil; Serviço de Dor do Hospital São Domingos (HSD), São Luís, MA, Brasil; Sociedade de Anestesiologia do Estado do Maranhão (Saem), São Luís, MA, Brasil.
• Rev Bras Anestesiol. 2015 Mar 1;65(2):92-8.

Background And ObjectivesInterleukin-6 (IL-6) is a predictor of trauma severity. The purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma IL-6 after hysterectomy.MethodA prospective, randomized, comparative, double-blind study with 40 patients, aged 18-60 years. G1 received lidocaine (2mg.kg(-1).h(-1)) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24hours), first analgesic request, and dose of morphine in 24hours were evaluated. IL-6 was measured before starting surgery (T0), five hours after the start (T5), and 24hours after the end of surgery (T24).ResultsThere was no difference in pain severity between groups. There was a decrease in pain severity between T0 and other measurement times in G1. Time to first supplementation was greater in G2 (76.0±104.4min) than in G1 (26.7±23.3min). There was no difference in supplemental dose of morphine between G1 (23.5±12.6mg) and G2 (18.7±11.3mg). There were increased concentrations of IL-6 in both groups from T0 to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5±364.1 ng.mL(-1) in T5 and 30.1±14.2 ng.mL(-1) in T24.ConclusionIntravenous lidocaine (2mg.kg(-1).h(-1)) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy.Copyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

7 keywords...

hide…