• Mara Greenberg, Tami J Daugherty, Arvand Elihu, Ravi Sharaf, Waldo Concepcion, Maurice Druzin, and Carlos O Esquivel.
• Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94304-1510, USA.
• Liver Transpl. 2009 Oct 1;15(10):1236-41.

AbstractOrthotopic liver transplantation (OLT) for acute liver failure (ALF) during pregnancy is an uncommon occurrence with variable outcomes. In pregnancy-related liver failure, prompt diagnosis and immediate delivery are essential for a reversal of the underlying process and for maternal and fetal survival. In rare cases, the reason for ALF during pregnancy is either unknown or irreversible, and thus OLT may be necessary. This case demonstrates the development of cryptogenic ALF during the 26th week of pregnancy in a woman with sickle cell disease. She underwent successful cesarean delivery of a healthy male fetus at 27 weeks with concurrent OLT. This report provides a literature review of OLT in pregnancy and examines the common causes of ALF in the pregnant patient. On the basis of the management and outcome of our case and the literature review, we present an algorithm for the suggested management of ALF in pregnancy.Copyright 2009 AASLD

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