• Neurology · May 2002

    Randomized Controlled Trial Clinical Trial

    Safety, tolerability, and efficacy of orally administered cannabinoids in MS.

    • J Killestein, E L J Hoogervorst, M Reif, N F Kalkers, A C Van Loenen, P G M Staats, R W Gorter, B M J Uitdehaag, and C H Polman.
    • Department of Neurology, VU Medical Center, Amsterdam, the Netherlands. J.Killestein@vumc.nl
    • Neurology. 2002 May 14;58(9):1404-7.

    AbstractThe authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.

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