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Neuroscience letters · Jun 2003
The dorsal portion of the lumbar intervertebral disc is innervated primarily by small peptide-containing dorsal root ganglion neurons in rats.
- Tomoyuki Ozawa, Yasuchika Aoki, Seiji Ohtori, Kazuhisa Takahashi, Tanemichi Chiba, Hidetoshi Ino, and Hideshige Moriya.
- Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, 260-8670, Japan.
- Neurosci. Lett. 2003 Jun 19;344(1):65-7.
AbstractThe intervertebral discs are innervated by the dorsal root ganglion (DRG) neurons. In the present study, we applied Fluoro-Gold (FG) to the dorsal portion of the L5-L6 intervertebral disc to label DRG neurons retrogradely, and then examined whether FG-labeled neurons were substance P (SP)-immunoreactive or isolectin B4 (IB4)-binding. Of the FG-labeled neurons, 44.0% were immunoreactive for SP, whereas only 0.6% were reactive for IB4. The rate of SP-immunoreactive neurons was significantly higher than that of IB4-binding neurons (P<0.001), suggesting that under physiological conditions the dorsal portion of the lumbar disc is mainly innervated by peptide-containing neurons.
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