• Jennifer Gray, Wences Arvelo, John McCracken, Beatriz Lopez, Fernanda C Lessa, Brandon Kitchel, Betty Wong, Lissette Reyes, and Kim Lindblade.
• Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala. jgray@slhs.org
• Am J Infect Control. 2012 Aug 1;40(6):516-20.

BackgroundGram-negative bloodstream infections are an important cause of neonatal mortality. In October 2009, we investigated a Klebsiella spp outbreak in a neonatal intensive care unit in Guatemala.MethodsProbable cases were defined as a Klebsiella spp isolated from blood in neonates aged <28 days in the neonatal intensive care unit between October 1 and November 10, 2009; confirmed cases were identified as Klebsiella pneumoniae. Clinical data were abstracted from medical charts. K pneumoniae isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and tested for antimicrobial susceptibility. Infection control practices were inspected.ResultsThere were 14 confirmed cases. The median age at onset of infection was 3 days (range, 2-8 days). Nine patients died (64%). K pneumoniae isolates were resistant to multiple antimicrobials. PFGE revealed 2 distinct clusters. Breaches in infection control procedures included inappropriate intravenous solution use and inadequate hand hygiene and contact precautions.ConclusionsWe report a K pneumoniae outbreak with high neonatal mortality in Guatemala. PFGE clustering suggested a common source possibly related to reuse of a single-use intravenous medication or solution. The risk for K pneumoniae bloodstream infections in neonates in low-resource settings where sharing of solutions is common needs to be emphasized.Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. All rights reserved.

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