• Perfusion · Jan 1996

    Randomized Controlled Trial Clinical Trial

    The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery bypass surgery.

    • R M Montesano, P A Gustafson, D A Palanzo, N J Manley, and F S Sadr.
    • Lehigh Valley Hospital, Allentown, Pennsylvania 18105, USA.
    • Perfusion. 1996 Jan 1;11(1):53-6.

    AbstractThe effect of low-dose epsilon-aminocaproic acid (EACA) on the postoperative course of 46 patients was studied. Patients undergoing coronary artery bypass grafting were randomly selected in two groups. Group 1 (20 patients) received 5 g EACA upon initiation of cardiopulmonary bypass (CPB). Group 2 (26 patients) received no antifibrinolytic drugs prior to CPB. Neither group received antifibrinolytic drugs after CPB. There was no significant difference between the two groups' blood usage on CPB: 0.65 units in Group 1 and 0.60 units in Group 2. After CPB, blood usage significantly differed: 2.2 +/- 1.7 (SD) units in Group 1 and 3.9 +/- 3.0 units in Group 2 (p = 0.033). Significant difference was also demonstrated in postoperative blood loss in the first 24 hours: 1610 +/- 531 ml in Group 1 versus 2025 +/- 804 ml in Group 2 (p = 0.043). Pre-CPB administration of low-dose EACA significantly decreases blood loss and blood usage in the postoperative period.

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