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Review Meta Analysis
Beta interferons in clinically isolated syndromes: a meta-analysis.
- Ailton Melo, Bernardo Rodrigues, and Amit Bar-Or.
- Division of Neurology and Epidemiology, Federal University of Bahia, Salvador, BA, Brazil. asm@ufba.br
- Arq Neuropsiquiatr. 2008 Mar 1;66(1):8-10.
AbstractBeta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.
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