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- J Ruiz-Ramos, M Gordon, M A Cortes, M J Broch, and P Ramirez.
- Intensive Care Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
- J Clin Pharm Ther. 2015 Jun 1;40(3):339-41.
What Is Known And ObjectivePositive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload.Case SummarySix patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of -2362 (-485 to -3447) mL. At the end of treatment, median fluid balance variation was -9080 (-26,784 to -4395) mL.What Is New And ConclusionTolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.© 2015 John Wiley & Sons Ltd.
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