• Antimicrob. Agents Chemother. · Jul 2006

    In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.

    • Cedric Jacqueline, Jocelyne Caillon, Olivier Grossi, Virginie Le Mabecque, Anne-Françoise Miegeville, Denis Bugnon, Eric Batard, and Gilles Potel.
    • Laboratoire d'Antibiologie (UPRES EA 3826), UER de Médecine, 44035 Nantes, Cedex 01, France.
    • Antimicrob. Agents Chemother. 2006 Jul 1;50(7):2547-9.

    AbstractLinezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

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