• Br J Anaesth · May 2000

    Cp50 of propofol with and without nitrous oxide 67%.

    • P C Stuart, S M Stott, A Millar, G N Kenny, and D Russell.
    • Department of Anaesthesia, University of Glasgow, UK.
    • Br J Anaesth. 2000 May 1;84(5):638-9.

    AbstractThe target concentration of propofol required to prevent response to surgical incision was determined in 60 unpremedicated ASA I or II patients, who breathed either oxygen-enriched air or nitrous oxide 67% in oxygen. Propofol was infused using a target-controlled infusion system incorporating the standard 'Diprifusor' pharmacokinetic model, with the target concentration for each patient decided by up/down sequential allocation. Presence or absence of movement in response to a groin incision was determined by the surgeon. The calculated blood concentration at which 50% of patients responded (Cp50calc), determined by probit analysis, was 6.8 micrograms ml-1 for patients who breathed oxygen-enriched air and 4.9 micrograms ml-1 for those who breathed nitrous oxide 67% in oxygen.

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