• Crit Care · Jul 2014

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    Getting older can be exhausting.

    • Rohit Mittal, Mandy L Ford, and Craig M Coopersmith.
    • Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, 101 Woodruff Circle, WMB Suite 5105, Atlanta, GA, 30345, USA. mittal@emory.edu.
    • Crit Care. 2014 Jul 29; 18 (4): 465.

    AbstractSepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission.

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