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Case Reports
Repair of cicatricial ectropion in an infant with harlequin ichthyosis using engineered human skin.
- Susan M Culican and Philip L Custer.
- Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri, USA.
- Am. J. Ophthalmol. 2002 Sep 1;134(3):442-3.
PurposeTo report the use of an Apligraf (Organogenesis, Inc., Canton, Massachusetts, USA) human skin equivalent for repair of cicatricial ectropion in a patient with harlequin ichthyosis.DesignInterventional case report.MethodsA 6-week-old male child with harlequin ichthyosis and severe bilateral upper eyelid cicatricial ectropion underwent repair with Apligraf grafts.ResultsAfter the initial repair with Apligraf grafts, recurrent bilateral upper eyelid ectropion developed, requiring repeat Apligraf grafting at age 61 days. After the second graft, the eyelids remained well positioned until the child's sudden death from respiratory failure at age 6 months.ConclusionApligraf human skin equivalent facilitated the repair of cicatricial ectropion in a child with harlequin ichthyosis.
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