• Acta Anaesthesiol Scand · Oct 2014

    Case Reports

    High-dose rocuronium for rapid-sequence induction and reversal with sugammadex in two myasthenic patients.

    • P Casarotti, C Mendola, G Cammarota, and F Della Corte.
    • Department of Translational Medicine, Maggiore Hospital School of Medicine, Novara, Italy.
    • Acta Anaesthesiol Scand. 2014 Oct 1;58(9):1154-8.

    AbstractThe anesthetic management of patients affected by myasthenia gravis is usually challenging in elective surgery and even more so in emergency procedures. The difficulties involved are several-fold, ranging from the choice of an appropriate muscle relaxant (i.e. one that enables safe and rapid airway management) to neuromuscular monitoring and normal muscular recovery. Additionally, optimizing patient conditions - either pharmacologically or with plasmapheresis - before intervention is well beyond the realm of possibility. We discuss the anesthetic management of two myasthenic patients undergoing emergency surgery (for sigmoid perforation and upper gastrointestinal bleeding respectively). In both cases, we opted for rapid-sequence induction with high-dose rocuronium to prevent inhalation of gastric contents. We also report on the implication of neuromuscular monitoring. We found that the rocuronium-sugammadex combination was a useful and effective option in the emergency setting.© 2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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