• W Teske, A Anastasiadis, J Krämer, and T Theodoridis.
• St. Josef-Hospital, Orthopädische Universitätsklinik, Gudrunstrasse 56, 44791, Bochum, Deutschland. w.teske@klinikum-bochum.de
• Orthopade. 2008 Dec 1;37(12):1210-6.

BackgroundThe efficacy and tolerability of oral controlled-release oxycodone in the therapy of musculoskeletal pain were analyzed in this observational study.Patients And MethodsA total of 843 patients with severe to most severe pain in the musculoskeletal system were treated with controlled-released oxycodone for 4 weeks or up to a maximum of 6 months. Severity of pain, impairment in quality of life, and mobility associated with the pain were assessed before and during therapy with controlled-release oxycodone by a numerical rating scale (NRS 0-10).ResultsPain intensity fell by an average of 65% within the first 4 weeks. Physical therapy was practicable in many patients only after implementation of a therapy regime with controlled-release oxycodone. Quality of life improved significantly under therapy with oxycodone, and the impairment of different aspects of life decreased by 50%.ConclusionThe therapy of pain of the musculoskeletal system with controlled-release oxycodone is efficient. An effective pain relief makes physical therapy practicable, reduces the impairment in different parts of life, and increases quality of life.

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