• Guihua Wang, Dawei Zhan, Laixing Li, Fumin Lei, Bohua Liu, Di Liu, Haixia Xiao, Youjun Feng, Jing Li, Baoan Yang, Zuohua Yin, Xiaohui Song, Xiaojia Zhu, Yanlong Cong, Juan Pu, Jian Wang, Jinhua Liu, George F Gao, and Qingyu Zhu.
• Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
• J. Gen. Virol. 2008 Mar 1;89(Pt 3):697-702.

AbstractHighly pathogenic avian influenza H5N1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of Lake Qinghai, 2005. In May 2006, another outbreak struck Lake Qinghai and six novel strains were isolated. To elucidate these QH06 viruses, the six isolates were subjected to whole-genome sequencing. Phylogenetic analyses show that QH06 viruses are derived from the lineages of Lake Qinghai, 2005. Five of the six novel isolates are adjacent to the strain A/Cygnus olor/Croatia/1/05, and the last one is related to the strain A/duck/Novosibirsk/02/05, an isolate of the flyway. Antigenic analyses suggest that QH06 and QH05 viruses are similar to each other. These findings implicate that QH06 viruses of Lake Qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of Lake Qinghai.

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