• Médecine sciences : M/S · Mar 2012

    Review

    [The emergence and development of gene expression profiling: a key component of the 3B (bench, bedside, bytes) in translational research].

    • Jean-Philippe Cointet, Andrei Mogoutov, Pascale Bourret, Rim El Abed, and Alberto Cambrosio.
    • Institut francilien recherche innovation société/université Paris-Est Marnela-Vallée, Champs-sur-Marne, France. jean-philippe.cointet@polytechnique.edu
    • Med Sci (Paris). 2012 Mar 1;28 Spec No 1:7-13.

    AbstractThis paper examines the emergence and development of one of the key components of genomics, namely gene expression profiling. It does so by resorting to computer-based methods to analyze and visualize networks of scientific publications. Our results show the central role played by oncology in this domain, insofar as the initial proof-of-principle articles based on a plant model organism have quickly led to the demonstration of the value of these techniques in blood cancers and to applications in the field of solid tumors, and in particular breast cancer. The article also outlines the essential role played by novel bioinformatics and biostatistical tools in the development of the domain. These computational disciplines thus qualify as one of the three corners (in addition to the laboratory and the clinic) of the translational research triangle.© 2012 médecine/sciences – Inserm / SRMS.

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