-
- J Cady.
- Department of Anesthesiology, Virginia Mason Medical Center, Seattle, WA, USA. jormain.cady@vmmc.org
- Oncol Nurs Forum. 2001 Nov 1;28(10):1561-8; quiz 1569-70.
Purpose/ObjectivesTo review opioid tolerance in chronic cancer pain, define the phenomenon and its scope, review physiologic mechanisms, and discuss clinical strategies to identify and manage this complex issue.Data SourcesReview articles, case studies, original research, and published guidelines.Data SynthesisNovel therapies to prevent/reverse tolerance are being investigated with a possible future role for N-methyl-d-aspartate antagonists.ConclusionsGreater nursing research is needed to identify patient risk factors for tolerance development and clinical measurement of the phenomenon. Understanding cellular mechanisms for tolerance may contribute to better management.Implications For Nursing PracticeNursing knowledge of tolerance is important to provide the basis for accurate patient assessment, education, and pain management.
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