• Headache · Apr 2015

    Review

    Opioid-induced central immune signaling: implications for opioid analgesia.

    • Peter M Grace, Steven F Maier, and Linda R Watkins.
    • University of Colorado Boulder, Boulder, CO, USA.
    • Headache. 2015 Apr 1;55(4):475-89.

    AbstractDespite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll-like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted.© 2015 American Headache Society.

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