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The Journal of pediatrics · Jul 1984
Recurrence of symptomatic patent ductus arteriosus in extremely premature infants, treated with indomethacin.
- M Mellander, B Leheup, D P Lindstrom, C Palme, T P Graham, M T Stahlman, and R B Cotton.
- J. Pediatr. 1984 Jul 1;105(1):138-43.
AbstractThe administration of a single intravenous injection of indomethacin was followed by a major constrictive effect on the ductus in 36 of 42 very-low-birth-weight (less than or equal to 1000 gm) infants with symptomatic patent ductus arteriosus (PDA). In 26 of the 36 responders, the effect was sustained; symptomatic PDA recurred in the remaining 10. Infants who experienced a recurrence of symptomatic PDA had lower birth weights and had received indomethacin at an earlier postnatal age than did infants with a sustained effect. These results may be explained by differences in the production and clearance of prostaglandins or in the sensitivity of the ductus to prostaglandin effects between infants with a recurrence and infants with sustained constriction of PDA.
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