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Comparative Study
Differential B and C fibre block by an amide- and an ester-linked local anaesthetic.
- J E Scurlock, J E Heavner, and R H de Jong.
- Br J Anaesth. 1975 Nov 1;47(11):1135-9.
AbstractThe relative sensitivity of sympathetic preganglionic and postganglionic axons, B and C fibres, respectively, to two structurally dissimilar local anaesthetics was examined. The concentration of amethocaine (ester-linked tertiary amine) or prilocaine (amide-linked secondary amine) required to reduce the B fibre compound action potential by 50% was one-third of the concentration required to depress the C fibre potential to a similar extent. Both local anaesthetic agents also showed the action potential propagation through B fibres more than through C fibres. Similar results have been reported previously for lignocaine (amide-linked tertiary amine).
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