• Hai Xue, Olafur Sveinsson, Torbjörn Tomson, and Tiit Mathiesen.
• Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, marcoxue2003@hotmail.com.
• Acta Neurochir (Wien). 2015 Sep 1;157(9):1541-8.

BackgroundSeizures are a common manifestation of brain tumors, but literature on the incidence of seizures before and after surgery for meningiomas is limited, and principles for use of antiepileptic drugs (AEDs) are controversial.MethodsThis review is based on a MEDLINE search for articles from 1994 to 2014 describing intracranial meningioma and seizures or epilepsy, and AEDs treatment during and after surgery.ResultsUp to 40 % of patients with symptomatic meningiomas present with seizures before operation. Tumor removal usually results in seizure control, but around 20 % of patients continue to have or develop new-onset seizures after surgery. Risk factors for seizures after surgery include preoperative seizures, tumor location, and extent of tumor removal. There are no solid data to support routine pre- or postoperative AED prophylaxis in seizure-free patients, and the decision to treat and the selection of AEDs should follow the general principles of treatment of focal epilepsies.ConclusionsSeizures are a common manifestation of meningiomas, but about 80 % patients with preoperative seizures can be seizure free after tumor removal. Prospective controlled AED trials specifically on meningioma patients are much needed.

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