• The Journal of urology · Dec 1993

    Case Reports

    Severe cyclophosphamide-induced hemorrhagic cystitis successfully treated by total cystectomy with ileal neobladder substitution: a case report.

    • T Okaneya, K Kontani, I Komiyama, and T Takezaki.
    • Department of Urology, Yamanashi Prefecture Central Hospital, Kofu, Japan.
    • J. Urol. 1993 Dec 1;150(6):1909-10.

    AbstractA 45-year-old woman with intractable cyclophosphamide-induced hemorrhagic cystitis was successfully treated with total cystectomy and ileal neobladder substitution. To our knowledge this is the first reported reconstruction of the lower urinary tract in a patient with acute hemorrhagic cystitis using a neobladder. Neobladder substitution is contraindicated if the urethra or bladder neck is involved in the disease, although neither was involved in our patient. Whether these lesions are generally left intact has not been discussed previously. If a neobladder can be used, life threatening hemorrhagic cystitis should be treated with total cystectomy accompanied by immediate neobladder substitution.

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