• Gao-wang Liu, Yong-sheng Shi, Jian-she Xu, Shi-ling Chen, and Ying Chen.
• Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
• Di Yi Jun Yi Da Xue Xue Bao. 2004 Nov 1;24(11):1304-5.

ObjectiveTo compare the clinical efficacy and safety of anesthesia with intravenous propofol combined with fentanyl for ultrasound-guided transvaginal oocyte retrieval.MethodsTotally 100 unpremedicated infertile women (ASA I-II) scheduled for oocyte retrieval with ultrasound guidance were randomly divided into two groups to receive anesthesia with either intravenous propofol (group A, n=50) or the combination of propofol and fentanyl (group B, n=50). The time when consciousness loss and recovery occurred, dosage of propofol for anesthesia maintenance, mean arterial blood pressure (MAP), heart rate (HR) and oxygen saturation (SpO2) were recorded.ResultsThere was no significant difference in the time of consciousness loss between groups A and B (58.8+/-3.8 s vs 57.7+/-5.2 s, P=0.283), but consciousness recovery occurred earlier in group B (6.0+/-0.6 min vs 5.7+/-0.4 min, P<0.01). The maintenance dosage of propofol in group B (0.20+/-0.03 mg/kg) was significantly lower than that in group A (0.52+/-0.05 mg/kg, P<0.01). At 2 min after anesthesia induction, the MAP decreased from 11.1+/-0.8 kPa to 8.0+/-0.6 kPa in group A (P<0.05), and from (10.9+/-0.9) kPa to (8.3+/-0.7) kPa in group B(P<0.05), and returned to normal within 2-3 min in both groups. The incidence of low SpO2 (<90%) was lower in group A than in group B ((52% vs 88%, P<0.001).ConclusionAnesthesia with propofol combined with fentanyl may reduce the maintenance dosage of propofol, shorten the time of consciousness recovery during oocyte retrieval with ultrasound guidance, and can be helpful for the patients' early recovery and discharge from hospital.

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