• Acta paediatrica · Jan 2012

    Cardiac troponin I concentrations in neonates with hypoxic-ischaemic encephalopathy.

    • Aravind T Shastri, Sujeevan Samarasekara, Hemananda Muniraman, and Paul Clarke.
    • Neonatal Unit, Norfolk & Norwich University Hospitals NHS Foundation Trust, Norfolk, UK.
    • Acta Paediatr. 2012 Jan 1;101(1):26-9.

    AimMyocardial dysfunction is a frequent sequel of perinatal asphyxia. Cardiac troponin I (cTnI) is a marker of myocardial injury and a surrogate marker of myocardial dysfunction in adults, but there are few data in neonates. Our aim was to compare serum cTnI concentrations with clinical severity of encephalopathy and with duration of inotropic support in asphyxiated neonates.MethodsRetrospective study of 60 neonates admitted with hypoxic-ischaemic encephalopathy (HIE). cTnI concentrations measured within 36 h of birth were compared with clinical grade of HIE (Sarnat-Sarnat classification) and with duration of inotropic support.ResultsSerum cTnI concentrations and duration of inotropic support were significantly greater with increasing severity of HIE. Median (95% CI) cTnI concentrations were 0.04 μg/L (0.02-0.07 μg/L) in grade 1 HIE, 0.12 μg/L (0.08-0.20 μg/L) in grade 2 HIE and 0.67 μg/L (0.41-1.35 μg/L) in grade 3 HIE. Median (95% CI) duration of inotropic support required was 0 h (0-24 h) in grade 1 HIE, 28 h (0-118 h) in grade 2 HIE and 48 h (0-140 h) in grade 3 HIE.ConclusionIn asphyxiated neonates, cTnI concentrations within 36 h of birth correlate strongly with clinical grade of HIE and with duration of inotropic support. Early cTnI concentrations may provide a useful proxy marker for the anticipated severity of myocardial dysfunction.© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

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