• Geraldo Rolim Rodrigues Júnior and José Luiz Gomes do Amaral.
• Departamento de Anestesiologia, FMB, UNESP.
• Rev Bras Anestesiol. 2002 Nov 1;52(6):747-55.

Background And ObjectivesAmong the most frequent indications for Intensive Care Unit patients sedation, one may mention artificial ventilation installation and maintenance, anxiety and uncomfortable or painful procedures. This retrospective study aimed at evaluating most common sedation indications and techniques for severe patients admitted to the Surgical Intensive Care Unit, Escola Paulista de Medicina (EPM/UNIFESP) during an 11-month period.MethodsAfter excluding patients remaining in the ICU for less than 24 hours and those without the necessary evaluation to determine their severity index (APACHE II), the sample was reduced to 307 patients. Most common techniques, sedation indications and neuromuscular blockers association were evaluated.ResultsSedation was administered to 37.4% of patients. Psychiatric disorders, such as delirium, agitation, fear and anxiety, were some indications for sedation and corresponded to 25.77% of all indications. Most ventilated patients also needed sedative agents and mechanical ventilation installation and maintenance represented most indications, or approximately 57.73% of all sedated patients. Procedures, such as tracheal intubation and bronchoscopy, represented 11.34% of all indications and metabolic control (barbiturate coma and tetanus) represented 5.15% of the cases. Most common sedative techniques included opioids alone or associated to benzodiazepines. In this study, fentanyl alone was used in 58% of the cases, and fentanyl plus midazolam in 21.64% of patients. Haloperidol, diazepam, propofol and thiopental added up 19.5%. Neuromuscular blockers were used in 22.7% of mechanically in ventilated patients.ConclusionsSedation is a common therapeutic resource for intensive care and is widely used to help mechanical ventilation and to treat psychiatric disorders. Fentanyl, alone or in association with midazolam, was the most widely used agent.

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