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Ann. N. Y. Acad. Sci. · Dec 2003
Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.
- Amandine Hurbin, Laurence Dubrez, Jean-Luc Coll, and Marie C Favrot.
- Groupe de Recherche sur le Cancer du Poumon, INSERM-U578, Institut Albert Bonniot, La Tronche 38706 Cedex, France. amandine.hurbin@ujf-grenoble.fr
- Ann. N. Y. Acad. Sci. 2003 Dec 1;1010:354-7.
AbstractThe reciprocal activation of amphiregulin (AR) and insulin-like growth factor-1 (IGF1) pathways has been shown to induce inhibition of serum deprivation apoptosis in non-small cell lung cancer (NSCLC) cell lines H358 and H322. We demonstrated that AR activated the IGF1 receptor (IGF1-R), which in turn induced the secretion of AR and IGF1. Transactivation of the IGF1-R by AR is independent of its binding to EGFR. Thus, AR can inhibit apoptosis in NSCLC cells through an IGF1-R-dependent pathway.
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