• Hum Exp Toxicol · May 1990

    Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage.

    • G J Beckett, J W Donovan, A J Hussey, A T Proudfoot, and L F Prescott.
    • University Department of Clinical Chemistry, Royal Infirmary, Edinburgh, Scotland, UK.
    • Hum Exp Toxicol. 1990 May 1;9(3):183-6.

    AbstractThe concentration of glutathione S-transferase B1 (GST B1) subunits was measured in sequential plasma samples taken at frequent intervals for 48 h from ten patients with severe paracetamol poisoning who were treated with intravenous N-acetylcysteine. No significant increase in plasma GST B1 concentration was observed over the study period and with 4 h of starting treatment with N-acetylcysteine there were significant decreases in plasma GST B1 concentrations. None of the patients subsequently developed significant liver damage. At the dose used for the treatment of paracetamol poisoning, N-acetylcysteine has no hepatotoxic effects.

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