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Clinics in chest medicine · Jun 2008
ReviewIs there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?
- Neil R MacIntyre.
- Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Box 3911, Room 1120, Erwin Road, Durham, NC 27710, USA. neil.macintyre@duke.edu
- Clin. Chest Med. 2008 Jun 1;29(2):233-9, v.
AbstractAirspace collapse is a hallmark of parenchymal lung injury. Strategies to reopen and maintain patency of these regions offer three advantages: improved gas exchange, less lung injury, and improved lung compliance. Elevations in intrathoracic pressure to achieve these goals, however, may overdistend healthier lung regions and compromise cardiac function. Positive expiratory-end pressure is a widely used technique to maintain alveolar patency, but its beneficial effects must be balanced against its harmful effects.
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