• Wolfgang Freund, Arthur P Wunderlich, Gregor Stuber, Florian Mayer, Peter Steffen, Martin Mentzel, Bernd Schmitz, and Frank Weber.
• Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany. freund-ulm@t-online.de
• Clin J Pain. 2011 Nov 1;27(9):796-804.

ObjectiveComplex regional pain syndrome I (CRPS I) is a frequent and debilitating condition with unclear etiology. Hypothesizing that maladaptive central processes play a crucial role in CRPS, the current study set out to explore cerebral activation during a task to suppress the feeling of pain under constant painful stimulation.MethodsTen individuals with CRPS I with symptoms on their left hand were subjected to electrical stimulation of both index fingers subsequently in a functional magnetic resonance imaging experiment. Their data were compared with 15 healthy controls.ResultsConcerning psychophysical measures, patients succeeded similarly as healthy controls in suppressing the feeling of pain. However, during constant painful stimulation and with the task to suppress the feeling of pain, there were significant differences in the interaction analyses of the corresponding cortical activation.DiscussionPatients differ from healthy controls by the activation pattern of cerebral areas that belong to the descending opioid pain suppression pathway: PAG and cingulate cortex are activated significantly less during suppression of pain, regardless of whether the symptomatic or asymptomatic hand was stimulated. Thus, there is a generalized functional change in individuals with CRPS I. However, it cannot be deducted whether the abnormality is causative or merely an effect, possibly maladaptive.

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