• Yashpal Singh, Anil P Singh, Gaurav Jain, Ghanshyam Yadav, and Dinesh Kumar Singh.
• Department of Anaesthesiology and Intensive Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
• Anesth Essays Res. 2015 May 1;9(2):155-60.

BackgroundAnesthetic agents should be chosen not only on the basis of safety-efficacy profile, but also on the economic aspect. Propofol and sevoflurane are commonly utilized anesthetic agent for general anesthesia.AimThe present study was designated to compare cost-effectiveness and recovery profile between propofol and sevoflurane for induction, maintenance or both.Settings And DesignRandomized controlled, participant and data operator blinded trial.Materials And MethodsNinety patients undergoing laparoscopic cholecystectomy were randomized into three equal groups to receive: Group P to receive injection propofol for both induction and maintenance; Group PS to receive injection propofol for induction and sevoflurane for maintenance; and Group S to receive sevoflurane for both induction and maintenance of general anesthesia, respectively. Cost analysis, hemodynamic parameter, and recovery profile were compared between these groups.Statistical AnalysisOne-way analysis of variance test or Fisher's exact test/Chi-square test whichever appropriate.ResultsTotal cost of anesthesia was highest in Group P and lowest in Group S. Mean time to extubation and time to follow verbal commands was lowest in Group S than Group P or Group P/S. Hemodynamic parameter was more stable in Group S.ConclusionWe conclude that sevoflurane appears to be better anesthetic agents in terms of cost-effectiveness and recovery profile.

4 keywords...

hide…