• Mol. Ther. · Jan 2013

    Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells.

    • Shin-ichiro Ohno, Masakatsu Takanashi, Katsuko Sudo, Shinobu Ueda, Akio Ishikawa, Nagahisa Matsuyama, Koji Fujita, Takayuki Mizutani, Tadaaki Ohgi, Takahiro Ochiya, Noriko Gotoh, and Masahiko Kuroda.
    • Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan.
    • Mol. Ther. 2013 Jan 1;21(1):185-91.

    AbstractDespite the therapeutic potential of nucleic acid drugs, their clinical application has been limited in part by a lack of appropriate delivery systems. Exosomes or microvesicles are small endosomally derived vesicles that are secreted by a variety of cell types and tissues. Here, we show that exosomes can efficiently deliver microRNA (miRNA) to epidermal growth factor receptor (EGFR)-expressing breast cancer cells. Targeting was achieved by engineering the donor cells to express the transmembrane domain of platelet-derived growth factor receptor fused to the GE11 peptide. Intravenously injected exosomes delivered let-7a miRNA to EGFR-expressing xenograft breast cancer tissue in RAG2(-/-) mice. Our results suggest that exosomes can be used therapeutically to target EGFR-expressing cancerous tissues with nucleic acid drugs.

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