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Review
Structural and physicochemical profiling of morphine and related compounds of therapeutic interest.
- K Mazák, S Hosztafi, A Rácz, and B Noszál.
- Semmelweis University, Department of Pharmaceutical Chemistry, Research Group of Drugs of Abuse, Hungarian Academy of Sciences, H-1092, Hogyes E. u. 9., Budapest, Hungary.
- Mini Rev Med Chem. 2009 Jul 1;9(8):984-95.
AbstractA concise account of the physicochemical properties of morphine and its derivatives of therapeutic interest is provided. Such properties include macroscopic and microscopic acid/base parameters, lipophilicity, solubility, permeability that all influence the fate of drugs in the body. The dependence of these parameters on pH is discussed and subsequent implications in drug administration and formulation are presented.
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