• A J Karayiannakis, A Zbar, G G Makri, K Syrigos, L Athanasiadis, D Alexiou, and E A Bastounis.
• First Department of Surgery, University of Athens, Laikon Hospital, Athens, Greece.
• Eur Surg Res. 1998 Jan 1;30(6):409-13.

AbstractThe associations between serum beta-endorphin levels and clinical and metabolic variables as well as beta-endorphin changes after surgically induced weight loss were investigated in 43 morbidly obese patients. A significant positive correlation between beta-endorphin and body weight, degree of body weight increase and ACTH was found preoperatively. Only body weight was independently associated with beta-endorphin levels. Twelve months following vertical banded gastroplasty, there was an extensive weight loss in all patients and improvement in their metabolic profile. A significant reduction in beta-endorphin levels which was proportional to the extent of weight loss was also observed.

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