• Anaesthesia · Sep 1987

    Case Reports

    Ketamine infusion. Its use as a sedative, inotrope and bronchodilator in a critically ill patient.

    • G R Park, A R Manara, L Mendel, and P E Bateman.
    • Intensive Care Unit, Addenbrooke's Hospital, Cambridge.
    • Anaesthesia. 1987 Sep 1;42(9):980-3.

    AbstractA patient with acute lymphatic leukaemia developed a bilateral fulminating Pseudomonas aeruginosa pneumonia and required controlled ventilation of the lungs. Marked agitation, hypotension and bronchospasm unresponsive to conventional bronchodilators presented a therapeutic challenge. A continuous intravenous infusion of midazolam failed to provide adequate sedation. A continuous intravenous infusion of ketamine resulted in better sedation, an increase in arterial pressure and a diminution of bronchospasm. The clinical improvement was maintained for the 5 days during which ketamine was infused. Plasma concentrations of ketamine and its metabolites are reported.

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